This house is significant as a contributing building in the Browne’s Addition Historic District and as the family home of David B. Fotheringham, a successful building contractor and community leader. Fotheringham lived in a temporary home situated next to this house as it was constructed. He finished in 1891, the same year he became Mayor of Spokane. After moving in, Fotheringham turned his attention to the lot across the street to the west, where he built the opulent Patrick Clark Mansion, designed by Spokane’s best known architect, Kirtland Cutter. Fotheringham remained in this house until 1926 when Fay E. and Ina Dobson purchased the home and converted it into an apartment building. In 1984, the house was partially restored and remodeled to accommodate a bed and breakfast, which continues to exist today.

Fotheringham Bed & Breakfast is a contributing property in the Browne’s Addition Historic District, which was listed on the National Register of Historic Places 7/30/1976 and the Browne's Addition Spokane Register Local Historic District Overlay Zone in 2019.